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Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs.
- Source :
-
Cell host & microbe [Cell Host Microbe] 2019 Nov 13; Vol. 26 (5), pp. 650-665.e4. - Publication Year :
- 2019
-
Abstract
- Antibiotics alter microbiota composition and increase infection susceptibility. However, the generalizable effects of antibiotics on and the contribution of environmental variables to gut commensals remain unclear. To address this, we tracked microbiota dynamics with high temporal and taxonomic resolution during antibiotic treatment in a controlled murine system by isolating variables such as diet, treatment history, and housing co-inhabitants. Human microbiotas were remarkably resilient and recovered during antibiotic treatment, with transient dominance of resistant Bacteroides and taxa-asymmetric diversity reduction. In certain cases, in vitro sensitivities were not predictive of in vivo responses, underscoring the significance of host and community context. A fiber-deficient diet exacerbated microbiota collapse and delayed recovery. Species replacement through cross housing after ciprofloxacin treatment established resilience to a second treatment. Single housing drastically disrupted recovery, highlighting the importance of environmental reservoirs. Our findings highlight deterministic microbiota adaptations to perturbations and the translational potential for modulating diet, sanitation, and microbiota composition during antibiotics.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Bacteroides classification
Bacteroides isolation & purification
Biodiversity
Ciprofloxacin pharmacology
Diet
Female
Gastrointestinal Tract drug effects
Germ-Free Life
Humans
Male
Mice
Rifaximin pharmacology
Streptomycin pharmacology
Anti-Bacterial Agents pharmacology
Bacterial Load drug effects
Bacteroides growth & development
Gastrointestinal Microbiome drug effects
Gastrointestinal Tract microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1934-6069
- Volume :
- 26
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cell host & microbe
- Publication Type :
- Academic Journal
- Accession number :
- 31726029
- Full Text :
- https://doi.org/10.1016/j.chom.2019.10.011