Survival outcomes of mucosal melanoma in the USA.

Authors :: Al-Haseni A
Vrable A
Qureshi MM
Mathews S
Pollock S
Truong MT
Sahni D
Source :: Future oncology (London, England) [Future Oncol] 2019 Dec; Vol. 15 (34), pp. 3977-3986. Date of Electronic Publication: 2019 Nov 14.
Publication Year :: 2019
Abstract: Background: Mucosal melanomas (MM) arise within the lining of the gastrointestinal (GI), genitourinary (GU) and head and neck (HN) systems.  Method: A retrospective analysis of the National Comprehensive Database identified 4,961 MM patients. Primary objective was to compare survival outcomes across the different locations.  Results: Overall survival for GI melanomas was significantly shorter than HN and GU melanomas. Median survival (95% confidence interval) was 19.5 (18.0-21.5), 26.4 (24.9-28.3), and 43.9 (38.8-47.8), months for GI, HN and GU cases, respectively (p<0.0001).  Conclusion: This is the largest study of MM in a US based population, demonstrating worse overall survival for GI MM in comparison to HN and GU melanomas.