Back to Search
Start Over
LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p.
- Source :
-
Aging [Aging (Albany NY)] 2019 Nov 13; Vol. 11 (21), pp. 9794-9810. Date of Electronic Publication: 2019 Nov 13. - Publication Year :
- 2019
-
Abstract
- The transcript factor LHX2 is dysregulated in many cancers but its role in osteosarcoma (OS) remains unclear. In this study, we confirm that LHX2 is up-regulated in osteosarcoma, and that its silencing inhibits OS malignancy and induces autophagy via mTOR signaling. We further demonstrate that miR-129-5p negatively regulates LHX2 and suppresses the malignant phenotypes of OS. LHX2 overexpression could restore the malignant phenotypes. In conclusion, LHX2 regulates tumorigenesis and autophagy via mTOR in OS and is negatively regulated by miR-129-5p. Targeting the miR-129-5p/LHX2/mTOR axis therefore represents a novel therapeutic strategy for OS treatment.
- Subjects :
- Autophagy
Bone Neoplasms etiology
Bone Neoplasms mortality
Cell Line, Tumor
Female
Gene Expression Regulation, Neoplastic
Humans
LIM-Homeodomain Proteins genetics
Male
Neoplasm Metastasis
Oncogenes
Osteosarcoma etiology
Osteosarcoma mortality
Signal Transduction
Transcription Factors genetics
Young Adult
Bone Neoplasms metabolism
LIM-Homeodomain Proteins metabolism
MicroRNAs metabolism
Osteosarcoma metabolism
TOR Serine-Threonine Kinases metabolism
Transcription Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1945-4589
- Volume :
- 11
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Aging
- Publication Type :
- Academic Journal
- Accession number :
- 31724536
- Full Text :
- https://doi.org/10.18632/aging.102427