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Natriuretic peptide system expression in murine and human submandibular salivary glands: a study of the spatial localisation of ANB, BNP, CNP and their receptors.
- Source :
-
Journal of molecular histology [J Mol Histol] 2020 Feb; Vol. 51 (1), pp. 3-13. Date of Electronic Publication: 2019 Nov 13. - Publication Year :
- 2020
-
Abstract
- The natriuretic peptide (NP) system comprises of three ligands, the Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors, NPRA, NPRB and NPRC. Here we present a comprehensive study of the natriuretic peptide system in healthy murine and human submandibular salivary glands (SMGs). We show CNP is the dominant NP in mouse and human SMG and is expressed together with NP receptors in ducts, autonomic nerves and the microvasculature of the gland, suggesting CNP autocrine signalling may take place in some of these glandular structures. These data suggest the NP system may control salivary gland function during homeostasis through the regulation of electrolyte re-absorption, neural stimulation and/or blood vessel wall contraction/relaxation. We also show abnormal expression of NPRA in the stroma of a subset of human SMGs resected from patients diagnosed with oral squamous cell carcinoma (OSCC) of non-salivary gland origin. This finding warrants further research to investigate a possible correlation between early OSCC invasion and NPRA overexpression.
- Subjects :
- Animals
Carcinoma, Squamous Cell blood supply
Carcinoma, Squamous Cell pathology
Female
Humans
Male
Mice
Mouth Neoplasms blood
Mouth Neoplasms pathology
Submandibular Gland blood supply
Submandibular Gland pathology
Atrial Natriuretic Factor biosynthesis
Carcinoma, Squamous Cell metabolism
Mouth Neoplasms metabolism
Natriuretic Peptide, Brain biosynthesis
Natriuretic Peptide, C-Type biosynthesis
Neoplasm Proteins biosynthesis
Receptors, Peptide biosynthesis
Submandibular Gland metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1567-2387
- Volume :
- 51
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of molecular histology
- Publication Type :
- Academic Journal
- Accession number :
- 31722080
- Full Text :
- https://doi.org/10.1007/s10735-019-09849-5