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Hybrid monoliths with metal-organic frameworks in spin columns for extraction of non-steroidal drugs prior to their quantitation by reversed-phase HPLC.
- Source :
-
Mikrochimica acta [Mikrochim Acta] 2019 Nov 11; Vol. 186 (12), pp. 759. Date of Electronic Publication: 2019 Nov 11. - Publication Year :
- 2019
-
Abstract
- A (glycidyl methacrylate)-co-(ethylene glycol dimethacrylate) polymer (poly(GMA-co-EDMA)) was functionalized with metal-organic frameworks (MOF) and used as a sorbent for solid-phase extraction (SPE). The polymeric sorbent was prepared in-situ by photopolymerization in a previously wall-modified spin column, and then modified with an amino-modified MOF of type NH <subscript>2</subscript> -MIL-101(Cr). The sorbents were used for the extraction of nonsteroidal anti-inflammatory drugs (NSAIDs) from human urine samples. The sorbent was compared with the parent monolith and embedded approach, where the MOF particles are admixed in the polymerization mixture before the in-situ polymerization in the modified spin column. SPE is performed by percolating the sample solutions in a centrifuge, which streamlines the SPE steps. The hybrid composites were characterized by scanning electron microscopy and nitrogen intrusion porosimetry. Three NSAIDs (ketoprofen, flurbiprofen, and ibuprofen) were tested. They were eluted from the sorbent with acidified water-acetonitrile mixtures and subsequently analyzed by reversed-phase HPLC with UV detection. The detection limits varied in the range from 0.1 to 7 μg·L <superscript>-1</superscript> , and the precisions (relative standard deviation) were <14% in all the cases. The recoveries were between 71.0 and 78.0% in spiked urine samples. Graphical abstractA hybrid monolith modified with amino-modified MOF [named NH <subscript>2</subscript> -MIL-101(Cr)] in wall-modified spin columns was prepared. The resulting micro-extraction device was applied to the extraction and preconcentration of non-steroidal anti-inflammatory drugs.
- Subjects :
- Adsorption
Anti-Inflammatory Agents, Non-Steroidal chemistry
Anti-Inflammatory Agents, Non-Steroidal urine
Chromatography, High Pressure Liquid
Chromatography, Reverse-Phase
Flurbiprofen chemistry
Flurbiprofen urine
Humans
Ibuprofen chemistry
Ibuprofen urine
Ketoprofen chemistry
Ketoprofen urine
Limit of Detection
Methylmethacrylates chemistry
Anti-Inflammatory Agents, Non-Steroidal isolation & purification
Flurbiprofen isolation & purification
Ibuprofen isolation & purification
Ketoprofen isolation & purification
Metal-Organic Frameworks chemistry
Solid Phase Microextraction methods
Subjects
Details
- Language :
- English
- ISSN :
- 1436-5073
- Volume :
- 186
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Mikrochimica acta
- Publication Type :
- Academic Journal
- Accession number :
- 31712934
- Full Text :
- https://doi.org/10.1007/s00604-019-3923-6