Efficacy of Bacteriophages in a Staphylococcus aureus Nondiabetic or Diabetic Foot Infection Murine Model.

Authors :: Albac S
Medina M
Labrousse D
Hayez D
Bonnot D
Anzala N
Laurent F
Ferry T
Dublanchet A
Chavanet P
Fevre C
Croisier D
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Jan 27; Vol. 64 (2). Date of Electronic Publication: 2020 Jan 27 (Print Publication: 2020).
Publication Year :: 2020
Abstract: This study investigated the in vivo efficacy of three bacteriophages combined compared with linezolid in two mouse models (nondiabetic and diabetic) of Staphylococcus aureus foot infection. In both models, a single injection of bacteriophages in the hindpaw showed significant antibacterial efficacy. Linezolid was as effective as bacteriophages in nondiabetic animals but ineffective in diabetic animals. These findings further support preclinical and clinical studies for the development of phage therapy.<br /> (Copyright © 2020 American Society for Microbiology.)

Subjects :: Animals
Diabetic Foot microbiology
Disease Models, Animal
Female
Mice
Mice, Inbred BALB C
Staphylococcal Infections microbiology
Anti-Bacterial Agents therapeutic use
Bacteriophages physiology
Diabetic Foot therapy
Linezolid therapeutic use
Phage Therapy
Staphylococcal Infections therapy
Staphylococcus aureus virology

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