Diverse and Flexible Transmission of fosA3 Associated with Heterogeneous Multidrug Resistance Regions in Salmonella enterica Serovar Typhimurium and Indiana Isolates.

Authors :: Fang LX
Jiang Q
Deng GH
He B
Sun RY
Zhang JF
Cen DJ
Miao YY
Wang D
Guo WY
Sun J
Liu YH
Liao XP
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Jan 27; Vol. 64 (2). Date of Electronic Publication: 2020 Jan 27 (Print Publication: 2020).
Publication Year :: 2020
Abstract: We identified fosA3 at a rate of 2.6% in 310 Salmonella isolates from food animals in Guangdong province, China. The fosA3 gene was genetically linked to diverse antibiotic resistance genes (ARGs), including mcr-1 , bla <subscript>CTX-M-14/55</subscript> , oqxAB , and rmtB These gene combinations were embedded in heterogeneous fosA3 -containing multidrug resistance regions on the transferable ST3-IncHI2 and F33:A-:B- plasmids and the chromosome. This indicated a great flexibility of fosA3 cotransmission with multiple important ARGs among Salmonella species.<br /> (Copyright © 2020 American Society for Microbiology.)

Subjects :: Bacterial Proteins genetics
Bacterial Proteins metabolism
Plasmids genetics
Salmonella Infections epidemiology
Salmonella typhimurium drug effects
Anti-Bacterial Agents pharmacology
Drug Resistance, Multiple, Bacterial genetics
Fosfomycin pharmacology
Salmonella Infections microbiology
Salmonella typhimurium genetics

Full Text Access

Tools