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Combination of G2-S16 dendrimer/dapivirine antiretroviral as a new HIV-1 microbicide.
- Source :
-
Future medicinal chemistry [Future Med Chem] 2019 Dec; Vol. 11 (23), pp. 3005-3013. Date of Electronic Publication: 2019 Nov 11. - Publication Year :
- 2019
-
Abstract
- Aim: To research the synergistic activity of G2-S16 dendrimer and dapivirine (DPV) antiretroviral as microbicide candidate to prevent HIV-1 infection. Materials & methods: We assess the toxicity of DPV on cell lines by MTT assay, the anti-HIV-1 activity of G2-S16 and DPV alone or combined at several fixed ratios. Finally, their ability to inhibit the bacterial growth in vitro was assayed. The analysis of combinatorial effects and the effective concentrations were performed with CalcuSyn software. Conclusion: Our results represent the first proof-of-concept study of G2-S16/DPV combination to develop a safe microbicide.
- Subjects :
- Animals
Anti-HIV Agents administration & dosage
Anti-HIV Agents toxicity
Bacteria, Anaerobic drug effects
Cell Line, Tumor
Cell Survival drug effects
Chlorocebus aethiops
Dendrimers administration & dosage
Dendrimers toxicity
Dose-Response Relationship, Drug
Drug Synergism
Epithelial Cells virology
HIV Infections prevention & control
Humans
Microbial Sensitivity Tests
Polyelectrolytes
Polymers
Pyrimidines administration & dosage
Pyrimidines toxicity
Silanes administration & dosage
Silanes toxicity
Vero Cells
Anti-HIV Agents pharmacology
Dendrimers pharmacology
Epithelial Cells drug effects
HIV-1 drug effects
Pyrimidines pharmacology
Silanes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1756-8927
- Volume :
- 11
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Future medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 31710246
- Full Text :
- https://doi.org/10.4155/fmc-2018-0539