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An Atmosphere-Breathing Refillable Biphasic Device for Cell Replacement Therapy.
- Source :
-
Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2019 Dec; Vol. 31 (52), pp. e1905135. Date of Electronic Publication: 2019 Nov 11. - Publication Year :
- 2019
-
Abstract
- Cell replacement therapy is emerging as a promising treatment platform for many endocrine disorders and hormone deficiency diseases. The survival of cells within delivery devices is, however, often limited due to low oxygen levels in common transplantation sites. Additionally, replacing implanted devices at the end of the graft lifetime is often unfeasible and, where possible, generally requires invasive surgical procedures. Here, the design and testing of a modular transcutaneous biphasic (BP) cell delivery device that provides enhanced and unlimited oxygen supply by direct contact with the atmosphere is presented. Critically, the cell delivery unit is demountable from the fixed components of the device, allowing for surgery-free refilling of the therapeutic cells. Mass transfer studies show significantly improved performance of the BP device in comparison to subcutaneous controls. The device is also tested for islet encapsulation in an immunocompetent diabetes rodent model. Robust cell survival and diabetes correction is observed following a rat-to-mouse xenograft. Lastly, nonsurgical cell refilling is demonstrated in dogs. These studies show the feasibility of this novel device for cell replacement therapies.<br /> (© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Animals
Cell Line
Cell- and Tissue-Based Therapy methods
Diabetes Mellitus, Experimental chemically induced
Diabetes Mellitus, Experimental therapy
Hydrocarbons chemistry
Insulin-Secreting Cells cytology
Insulin-Secreting Cells metabolism
Insulin-Secreting Cells transplantation
Mice
Mice, Inbred C57BL
Nanostructures chemistry
Oxygen metabolism
Polymers chemistry
Polytetrafluoroethylene chemistry
Rats
Rats, Sprague-Dawley
Titanium chemistry
Cell- and Tissue-Based Therapy instrumentation
Membranes, Artificial
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4095
- Volume :
- 31
- Issue :
- 52
- Database :
- MEDLINE
- Journal :
- Advanced materials (Deerfield Beach, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 31709667
- Full Text :
- https://doi.org/10.1002/adma.201905135