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H 2 FPEF Score for the Prediction of Exercise Intolerance and Abnormal Hemodynamics in Japanese - Evaluation by Exercise Stress Echocardiography Combined With Cardiopulmonary Exercise Testing.
- Source :
-
Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2019 Nov 25; Vol. 83 (12), pp. 2487-2493. Date of Electronic Publication: 2019 Nov 08. - Publication Year :
- 2019
-
Abstract
- Background: Both the H <subscript>2</subscript> FPEF-score and nomogram-score, which consist of simple clinical parameters, can assist in diagnosing "early" heart failure with preserved ejection fraction (HFpEF) and only exertional dyspnea, but their these usefulness in Japanese remains unclear. We sought to investigate the correlation between these scores and exercise response, including the peak oxygen uptake (V̇O <subscript>2</subscript> ), the pulmonary artery systolic pressure (PASP), the ratio of early diastolic transmitral flow velocity to early diastolic mitral annular velocity (E/e') and stroke volume (SV) using exercise stress echocardiography (ESE) combined with cardiopulmonary exercise testing (CPET).Methods and Results:In this single-center, retrospective cross-sectional study the H <subscript>2</subscript> FPEF-score and nomogram-score were calculated in a total of 139 patients who underwent ESE combined with CPET. The scores correlated with peak V̇O <subscript>2</subscript> (r=-0.48, r=-0.44), PASP (r=0.23, r=0.29) and SV (r=-0.32, r=-0.19) at peak exercise. The nomogram-score correlated with E/e' (r=0.24). The prevalence of exercise intolerance (percent predicted peak V̇O <subscript>2</subscript> <75% and <50%) increased as the H <subscript>2</subscript> FPEF-score increased and reached 88.9% and 22.2% among the patients with high H <subscript>2</subscript> FPEF-score (6-9 points).<br />Conclusions: The H <subscript>2</subscript> FPEF-score may be useful as the initial step to diagnosing 'early' HFpEF. The nomogram-score may be more useful in Japanese because of its more universal association with exercise response than the H <subscript>2</subscript> FPEF-score.
- Subjects :
- Adult
Aged
Aged, 80 and over
Cross-Sectional Studies
Early Diagnosis
Female
Heart Failure physiopathology
Humans
Japan
Male
Middle Aged
Oxygen Consumption
Predictive Value of Tests
Reproducibility of Results
Retrospective Studies
Young Adult
Echocardiography, Stress
Exercise Test
Exercise Tolerance
Heart Failure diagnosis
Hemodynamics
Nomograms
Subjects
Details
- Language :
- English
- ISSN :
- 1347-4820
- Volume :
- 83
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Circulation journal : official journal of the Japanese Circulation Society
- Publication Type :
- Academic Journal
- Accession number :
- 31708523
- Full Text :
- https://doi.org/10.1253/circj.CJ-19-0699