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TwinssCan - Gene-Environment Interaction in Psychotic and Depressive Intermediate Phenotypes: Risk and Protective Factors in a General Population Twin Sample.
- Source :
-
Twin research and human genetics : the official journal of the International Society for Twin Studies [Twin Res Hum Genet] 2019 Dec; Vol. 22 (6), pp. 460-466. Date of Electronic Publication: 2019 Nov 11. - Publication Year :
- 2019
-
Abstract
- Meta-analyses suggest that clinical psychopathology is preceded by dimensional behavioral and cognitive phenotypes such as psychotic experiences, executive functioning, working memory and affective dysregulation that are determined by the interplay between genetic and nongenetic factors contributing to the severity of psychopathology. The liability to mental ill health can be psychometrically measured using experimental paradigms that assess neurocognitive processes such as salience attribution, sensitivity to social defeat and reward sensitivity. Here, we describe the TwinssCan, a longitudinal general population twin cohort, which comprises 1202 individuals (796 adolescent/young adult twins, 43 siblings and 363 parents) at baseline. The TwinssCan is part of the European Network of National Networks studying Gene-Environment Interactions in Schizophrenia project and recruited from the East Flanders Prospective Twin Survey. The main objective of this project is to understand psychopathology by evaluating the contribution of genetic and nongenetic factors on subclinical expressions of dimensional phenotypes at a young age before the onset of disorder and their association with neurocognitive processes, such as salience attribution, sensitivity to social defeat and reward sensitivity.
- Subjects :
- Adolescent
Adult
Belgium epidemiology
Depressive Disorder genetics
Depressive Disorder pathology
Diseases in Twins genetics
Diseases in Twins pathology
Female
Humans
Incidence
Longitudinal Studies
Male
Neurocognitive Disorders genetics
Neurocognitive Disorders pathology
Prospective Studies
Protective Factors
Risk Factors
Social Environment
Young Adult
Depressive Disorder epidemiology
Diseases in Twins epidemiology
Gene-Environment Interaction
Neurocognitive Disorders epidemiology
Twins, Dizygotic genetics
Twins, Monozygotic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1832-4274
- Volume :
- 22
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Twin research and human genetics : the official journal of the International Society for Twin Studies
- Publication Type :
- Academic Journal
- Accession number :
- 31708010
- Full Text :
- https://doi.org/10.1017/thg.2019.96