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Effect of Zataria multiflora on serum cytokine levels and pulmonary function tests in sulfur mustard-induced lung disorders: A randomized double-blind clinical trial.
- Source :
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Journal of ethnopharmacology [J Ethnopharmacol] 2020 Feb 10; Vol. 248, pp. 112325. Date of Electronic Publication: 2019 Nov 09. - Publication Year :
- 2020
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Abstract
- Ethnopharmacological Relevance: Zataria multiflora (Z. multiflora) belongs to the Lamiaceae family and has several traditional uses owing to its antiseptic, aesthetic, antispasmodic, analgesic, and antidiarrheal properties.<br />Aim of the Study: We aimed to investigate the effect of Z. multiflora on serum cytokine levels and pulmonary function tests (PFT) in patients exposed to sulfur mustard (SM) for a long term (27-30 years).<br />Materials and Methods: Thirty-five patients were randomly assigned to the placebo group (P) and two experimental groups treated with Z. multiflora extracts, i.e., 5 and 10 mg/kg/day (Z5 and Z10). Serum levels of cytokines including IL (2, 4, 6, 8, and 10) and IFN-γ as well as PFT indices such as maximum mid-expiratory flow (MMEF) and maximum expiratory flow at 25, 50, and 75% of vital capacity (VC) (MEF25, 50, and 75) were assessed at the beginning (phase 0) and at the end of 4 and 8 weeks (phases I and II, respectively) after starting the treatment.<br />Results: Serum levels of IL-2, IL-6, and IL-8 were significantly decreased, while serum levels of IL-10 and IFN-γ were significantly increased in the Z5 and Z10 treatment groups in phases I and II as compared to those in phase 0 (p < 0.05 to p < 0.001). MMEF and MEF25, 50, and 75 values were significantly increased in the Z5 group in phase II and in the Z10 group in phases I and II compared to those in phase 0 (p < 0.05 to p < 0.001). The percent change in serum cytokine levels and the change in MEF25, 50, and 75 during the two-month treatment period were significantly higher in the treatment groups than in the placebo group.<br />Conclusions: Two months of treatment with Z. multiflora reduced inflammation, while it enhanced anti-inflammatory cytokines and improved PFT indices in SM-exposed patients.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Anti-Inflammatory Agents adverse effects
Female
Humans
Iran
Lung metabolism
Lung physiopathology
Lung Injury blood
Lung Injury chemically induced
Lung Injury physiopathology
Male
Middle Aged
Plant Extracts adverse effects
Pneumonia blood
Pneumonia chemically induced
Pneumonia physiopathology
Time Factors
Treatment Outcome
Anti-Inflammatory Agents therapeutic use
Chemical Warfare Agents poisoning
Cytokines blood
Inflammation Mediators blood
Lamiaceae
Lung drug effects
Lung Injury drug therapy
Mustard Gas poisoning
Plant Extracts therapeutic use
Pneumonia drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7573
- Volume :
- 248
- Database :
- MEDLINE
- Journal :
- Journal of ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 31707049
- Full Text :
- https://doi.org/10.1016/j.jep.2019.112325