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New triterpenoids and PTP1B inhibitory constituents of Pseudolarix amabilis.
- Source :
-
Fitoterapia [Fitoterapia] 2019 Nov; Vol. 139, pp. 104414. Date of Electronic Publication: 2019 Nov 06. - Publication Year :
- 2019
-
Abstract
- Six new triterpenoids, pseudolarins A-F (1-6), were isolated from the twigs of Pseudolarix amabilis, together with four known triterpenoids (7-10) and five known diterpenoids (11-15). Their structures were determined by extensive spectroscopic analysis, and the absolute configuration of 1 was assigned by single-crystal X-ray diffraction. Compound 1 is a 3,4:9,10-diseco-cycloartane triterpenoid possessing an unprecedented 5/5/7/6/5/6/5 ring system. Compounds 1, 5, 7, 9-11, and 13 showed inhibition against protein tyrosine phosphatase 1B (PTP1B) in vitro.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- China
Diterpenes isolation & purification
Molecular Structure
Phytochemicals isolation & purification
Phytochemicals pharmacology
Triterpenes isolation & purification
Diterpenes pharmacology
Pinaceae chemistry
Protein Tyrosine Phosphatase, Non-Receptor Type 1 antagonists & inhibitors
Triterpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 139
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 31705950
- Full Text :
- https://doi.org/10.1016/j.fitote.2019.104414