Back to Search
Start Over
Primary Pediatric Non-Hodgkin Lymphomas of the Gastrointestinal Tract: A Population-based Analysis.
- Source :
-
Anticancer research [Anticancer Res] 2019 Nov; Vol. 39 (11), pp. 6413-6416. - Publication Year :
- 2019
-
Abstract
- Background/aim: The aim of this study was to present the clinical characteristics, natural history and survival outcomes of primary gastrointestinal non-Hodgkin lymphomas (PGINHL) in the pediatric population.<br />Patients and Methods: Surveillance, Epidemiology, and End Results (SEER) database was queried for patients aged 0 to 19 years with PGINHL between 1973 and 2014.<br />Results: A total of 452 cases were identified [mean age 11.0 (±5.1)] years, whites 84.1%, males (76.5%). The majority of tumors were noted in the small bowel (SB) (47.6%), followed by large bowel (LB) (28.5%) and the stomach (10.0%). Overall, the most common histological subtype was Burkitt lymphoma (51.8%), followed by diffuse large B-cell lymphoma (DLBCL) (26.1%). Mean overall survival (OS) of the entire cohort was 33,33 years with a 5-yr, 10-yr and 30-yr survival rate of 86%, 86% and 79%, respectively. Large bowel tumors had the best long-term survival rates whereas; gastric tumors had the worst with 30-yr survival rate 84% and 74%, respectively. Overall, 328 (72.6%) patients received surgery. No significant survival difference was noted between patients who underwent surgery and those who did not.<br />Conclusion: This study presents the largest dataset of pediatric PGINHL and describes the clinical features and outcomes of these patients in addition to summarizing the literature.<br /> (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Adolescent
Burkitt Lymphoma mortality
Burkitt Lymphoma pathology
Burkitt Lymphoma surgery
Cecal Neoplasms mortality
Cecal Neoplasms pathology
Cecal Neoplasms surgery
Child
Child, Preschool
Female
Humans
Ileal Neoplasms mortality
Ileal Neoplasms pathology
Ileal Neoplasms surgery
Infant
Infant, Newborn
Lymphoma, Large B-Cell, Diffuse mortality
Lymphoma, Large B-Cell, Diffuse pathology
Lymphoma, Large B-Cell, Diffuse surgery
Male
SEER Program
Stomach Neoplasms mortality
Stomach Neoplasms pathology
Stomach Neoplasms surgery
Survival Rate
Young Adult
Gastrointestinal Neoplasms mortality
Gastrointestinal Neoplasms pathology
Gastrointestinal Neoplasms surgery
Lymphoma, Non-Hodgkin mortality
Lymphoma, Non-Hodgkin pathology
Lymphoma, Non-Hodgkin surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 39
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 31704875
- Full Text :
- https://doi.org/10.21873/anticanres.13855