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Netrin Synergizes Signaling and Adhesion through DCC.
- Source :
-
Trends in biochemical sciences [Trends Biochem Sci] 2020 Jan; Vol. 45 (1), pp. 6-12. Date of Electronic Publication: 2019 Nov 05. - Publication Year :
- 2020
-
Abstract
- Netrin is a prototypical axon guidance cue. Structural studies have revealed how netrin interacts with the deleted in colorectal cancer (DCC) receptor, other receptors, and co-factors for signaling. Recently, genetic studies suggested that netrin is involved in neuronal haptotaxis, which requires a reversible adhesion process. Structural data indicate that netrin can also mediate trans-adhesion between apposing cells decorated with its receptors on the condition that the auxiliary guidance cue draxin is present. Here, we propose that netrin is involved in conditional adhesion, a reversible and localized process that can contribute to cell adhesion and migration. We suggest that netrin-mediated adhesion and signaling are linked, and that local environmental factors in the ventricular zone, the floor plate, or other tissues coordinate its function.<br /> (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 0968-0004
- Volume :
- 45
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Trends in biochemical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 31704057
- Full Text :
- https://doi.org/10.1016/j.tibs.2019.10.005