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Inhibition of DNA demethylation enhances plant tolerance to cadmium toxicity by improving iron nutrition.
- Source :
-
Plant, cell & environment [Plant Cell Environ] 2020 Jan; Vol. 43 (1), pp. 275-291. Date of Electronic Publication: 2019 Nov 12. - Publication Year :
- 2020
-
Abstract
- Although the alteration of DNA methylation due to abiotic stresses, such as exposure to the toxic metal cadmium (Cd), has been often observed in plants, little is known about whether such epigenetic changes are linked to the ability of plants to adapt to stress. Herein, we report a close linkage between DNA methylation and the adaptational responses in Arabidopsis plants under Cd stress. Exposure to Cd significantly inhibited the expression of three DNA demethylase genes ROS1/DML2/DML3 (RDD) and elevated DNA methylation at the genome-wide level in Col-0 roots. Furthermore, the profile of DNA methylation in Cd-exposed Col-0 roots was similar to that in the roots of rdd triple mutants, which lack RDD, indicating that Cd-induced DNA methylation is associated with the inhibition of RDD. Interestingly, the elevation in DNA methylation in rdd conferred a higher tolerance against Cd stress and improved cellular Fe nutrition in the root tissues. In addition, lowering the Fe supply abolished improved Cd tolerance due to the lack of RDD in rdd. Together, these data suggest that the inhibition of RDD-mediated DNA demethylation in the roots by Cd would in turn enhance plant tolerance to Cd stress by improving Fe nutrition through a feedback mechanism.<br /> (© 2019 John Wiley & Sons Ltd.)
- Subjects :
- Adaptation, Physiological
Arabidopsis drug effects
Arabidopsis Proteins genetics
Cadmium metabolism
DNA Glycosylases metabolism
DNA Methylation
DNA Transposable Elements
Drug Tolerance genetics
Gene Expression Regulation, Plant drug effects
Genes, Plant
Mutation
Nuclear Proteins metabolism
Plant Roots metabolism
Stress, Physiological
Arabidopsis genetics
Arabidopsis metabolism
Arabidopsis Proteins metabolism
Cadmium toxicity
DNA Demethylation
Drug Tolerance physiology
Iron metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1365-3040
- Volume :
- 43
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Plant, cell & environment
- Publication Type :
- Academic Journal
- Accession number :
- 31703150
- Full Text :
- https://doi.org/10.1111/pce.13670