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Tissue remodelling in chronic rhinosinusitis - review of literature.

Tissue remodelling in chronic rhinosinusitis - review of literature.

Authors :
Radajewski K
Wierzchowska M
Grzanka D
Antosik P
Zdrenka M
Burduk P
Source :
Otolaryngologia polska = The Polish otolaryngology [Otolaryngol Pol] 2019 Sep 02; Vol. 73 (5), pp. 1-4.
Publication Year :
2019

Abstract

CRS is a process involving a number of adverse changes in the mucosa of the paranasal sinuses and nasal polyps, e.g. increased fibroblast proliferation, angiogenesis, increased formation of fibrous tissue (subepithelial fibrosis) and tissue destruction. There are biomarkers whose levels can be increased in chronic inflammation of the paranasal sinuses: peripheral blood eosinophilia, IgE immunoglobulin, cytokines - IL-4, IL-5, IL-13, IL-25, IL-33, periostin, P-glycoprotein, CXCL-12, CXCL-13, INF-Υ, TNFα, TGFβ1, albumins, eotaxin. These biomarkers are not pathognomonic for CRS. The concentration of biomarkers is also increased in bronchial asthma and atopic dermatitis. The TGFβ, in particular, the β1 subunit, was identified as the main factor involved in the remodeling of tissue stroma. In conjunction with the continuous improvement of tissue testing methods, it is advisable to search for new factors that will more accurately allow the assessment of tissue remodeling in the chronic processes of paranasal sinuses.

Details

Language :
English
ISSN :
2300-8423
Volume :
73
Issue :
5
Database :
MEDLINE
Journal :
Otolaryngologia polska = The Polish otolaryngology
Publication Type :
Academic Journal
Accession number :
31701902
Full Text :
https://doi.org/10.5604/01.3001.0013.4121