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Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients.
- Source :
-
Nature medicine [Nat Med] 2019 Nov; Vol. 25 (11), pp. 1728-1732. Date of Electronic Publication: 2019 Nov 07. - Publication Year :
- 2019
-
Abstract
- Probiotics are routinely administered to hospitalized patients for many potential indications <superscript>1</superscript> but have been associated with adverse effects that may outweigh their potential benefits <superscript>2-7</superscript> . It is particularly alarming that probiotic strains can cause bacteremia <superscript>8,9</superscript> , yet direct evidence for an ancestral link between blood isolates and administered probiotics is lacking. Here we report a markedly higher risk of Lactobacillus bacteremia for intensive care unit (ICU) patients treated with probiotics compared to those not treated, and provide genomics data that support the idea of direct clonal transmission of probiotics to the bloodstream. Whole-genome-based phylogeny showed that Lactobacilli isolated from treated patients' blood were phylogenetically inseparable from Lactobacilli isolated from the associated probiotic product. Indeed, the minute genetic diversity among the blood isolates mostly mirrored pre-existing genetic heterogeneity found in the probiotic product. Some blood isolates also contained de novo mutations, including a non-synonymous SNP conferring antibiotic resistance in one patient. Our findings support that probiotic strains can directly cause bacteremia and adaptively evolve within ICU patients.
- Subjects :
- Bacteremia blood
Bacteremia etiology
Bacteremia microbiology
Diarrhea blood
Diarrhea etiology
Diarrhea genetics
Diarrhea microbiology
Genetic Variation genetics
Genome, Bacterial genetics
Genomics
Humans
Intensive Care Units
Lactobacillus genetics
Mutation
Phylogeny
Polymorphism, Single Nucleotide genetics
Probiotics therapeutic use
Whole Genome Sequencing
Bacteremia genetics
Drug Resistance, Bacterial genetics
Lactobacillus pathogenicity
Probiotics adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1546-170X
- Volume :
- 25
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Nature medicine
- Publication Type :
- Academic Journal
- Accession number :
- 31700189
- Full Text :
- https://doi.org/10.1038/s41591-019-0626-9