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Polyprenylated xanthones from the twigs and leaves of Garcinia nujiangensis and their cytotoxic evaluation.
- Source :
-
Bioorganic chemistry [Bioorg Chem] 2020 Jan; Vol. 94, pp. 103370. Date of Electronic Publication: 2019 Oct 24. - Publication Year :
- 2020
-
Abstract
- Inspired by the intriguing structures and bioactivities of polyprenylated xanthones, ten previously undescribed polyprenylated xanthones, nujiangxanthones G-P (1-10), and fifteen known ones (11-25) were isolated from the twigs and leaves of Garcinia nujiangensis. The structures of these compounds were established on the basis of spectroscopic data as well as comparison with the literature. Most of the isolates showed potent cytotoxicity against selected cancer cells. Compound 8 showed the highest effects against MDA-MB-231 and A549 cell lines with IC <subscript>50</subscript> values of 4.12 and 2.67 μM and 16 demonstrated the most potent activity against MCF-7 cell line with an IC <subscript>50</subscript> value of 3.36 μM.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic isolation & purification
Cell Line, Tumor
Cell Proliferation drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Plant Leaves chemistry
Plant Stems chemistry
Structure-Activity Relationship
Xanthones chemistry
Xanthones isolation & purification
Antineoplastic Agents, Phytogenic pharmacology
Garcinia chemistry
Xanthones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2120
- Volume :
- 94
- Database :
- MEDLINE
- Journal :
- Bioorganic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 31699388
- Full Text :
- https://doi.org/10.1016/j.bioorg.2019.103370