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Long-term Respiratory Effects of Mustard Vesicants.
- Source :
-
Toxicology letters [Toxicol Lett] 2020 Feb 01; Vol. 319, pp. 168-174. Date of Electronic Publication: 2019 Nov 04. - Publication Year :
- 2020
-
Abstract
- Sulfur mustard and related vesicants are cytotoxic alkylating agents that cause severe damage to the respiratory tract. Injury is progressive leading, over time, to asthma, bronchitis, bronchiectasis, airway stenosis, and pulmonary fibrosis. As there are no specific therapeutics available for victims of mustard gas poisoning, current clinical treatments mostly provide only symptomatic relief. In this article, the long-term effects of mustards on the respiratory tract are described in humans and experimental animal models in an effort to define cellular and molecular mechanisms contributing to lung injury and disease pathogenesis. A better understanding of mechanisms underlying pulmonary toxicity induced by mustards may help in identifying potential targets for the development of effective clinical therapeutics aimed at mitigating their adverse effects.<br /> (Copyright © 2019. Published by Elsevier B.V.)
- Subjects :
- Animals
Humans
Lung pathology
Lung Injury chemically induced
Lung Injury drug therapy
Lung Injury pathology
Pulmonary Fibrosis chemically induced
Pulmonary Fibrosis drug therapy
Pulmonary Fibrosis pathology
Respiratory Tract Diseases drug therapy
Respiratory Tract Diseases pathology
Alkylating Agents toxicity
Chemical Warfare Agents toxicity
Mustard Compounds toxicity
Respiratory Tract Diseases chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1879-3169
- Volume :
- 319
- Database :
- MEDLINE
- Journal :
- Toxicology letters
- Publication Type :
- Academic Journal
- Accession number :
- 31698045
- Full Text :
- https://doi.org/10.1016/j.toxlet.2019.10.026