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Morphology, p16, HPV, and outcomes in squamous cell carcinoma of the penis: a multi-institutional study.
- Source :
-
Human pathology [Hum Pathol] 2020 Feb; Vol. 96, pp. 79-86. Date of Electronic Publication: 2019 Nov 05. - Publication Year :
- 2020
-
Abstract
- Our objective was to evaluate the pathologic features and clinical outcomes in cases of invasive penile squamous cell carcinoma (SCC) and the association with p16 immunohistochemistry (IHC) and human papilloma virus (HPV) in situ hybridization (ISH). A retrospective multi-institutional database search was conducted for invasive SCC of the penis diagnosed between 2007 and 2018 that had undergone surgical resection. Pathologic features, p16 IHC, and HPV ISH were investigated with clinical outcomes. A total of 102 patients were included in the study. The average age was 63 ± 13.3 years. Based on histology, 46% of tumors displayed an HPV-related subtype, whereas p16 was positive in 52% of all cases. Tumor histology correlated well with p16 positivity (P < .001), and p16 IHC accurately predicted the presence of HPV in 25/26 (96%) cases. On multivariate analysis, perineural invasion was associated with local disease recurrence (P = .02), whereas lymphovascular invasion was associated with progression to metastatic disease (P = .002) and increased overall mortality (P = .02). Urethral involvement was also associated with increased overall mortality (P = .02). In addition, HPV-related tumors based on histologic features correlated with lower rates of metastatic disease (P = .007). HPV is a common cause of penile SCC and can be diagnosed by tumor histology and confirmed by overexpression of p16 on IHC. The presence of lymphovascular invasion, perineural invasion, and urethral involvement are poor prognostic indicators, whereas HPV-related tumors based on histology may have lower risk for metastatic disease.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Biopsy
Databases, Factual
Disease Progression
Host-Pathogen Interactions
Human Papillomavirus DNA Tests
Humans
Immunohistochemistry
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local
Retrospective Studies
Risk Assessment
Risk Factors
Treatment Outcome
United States
Biomarkers, Tumor analysis
Carcinoma, Squamous Cell chemistry
Carcinoma, Squamous Cell secondary
Carcinoma, Squamous Cell surgery
Carcinoma, Squamous Cell virology
Cyclin-Dependent Kinase Inhibitor p16 analysis
Papillomaviridae genetics
Papillomavirus Infections virology
Penile Neoplasms chemistry
Penile Neoplasms pathology
Penile Neoplasms surgery
Penile Neoplasms virology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8392
- Volume :
- 96
- Database :
- MEDLINE
- Journal :
- Human pathology
- Publication Type :
- Academic Journal
- Accession number :
- 31698006
- Full Text :
- https://doi.org/10.1016/j.humpath.2019.09.013