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Progesterone increases the incidence of bovine herpesvirus 1 reactivation from latency and stimulates productive infection.
- Source :
-
Virus research [Virus Res] 2020 Jan 15; Vol. 276, pp. 197803. Date of Electronic Publication: 2019 Nov 04. - Publication Year :
- 2020
-
Abstract
- Bovine herpesvirus 1 (BoHV-1), including modified live vaccines, can cause abortions in pregnant cows. Progesterone maintains pregnancy and promotes spermiogenesis and testosterone biosynthesis in males: furthermore, progesterone is a neuro-steroid. Recent published studies demonstrated progesterone stimulated the BoHV-1 immediate early transcription unit 1 (IEtu1) promoter, and two glucocorticoid receptor response elements within the promoter were required for progesterone mediated transactivation. In this study, we tested whether progesterone induces reactivation from latency in rabbits. As expected, the synthetic corticosteroid dexamethasone consistently induced reactivation from latency in males and females. While progesterone induced reactivation from latency in approximately one-half of male rabbits, virus shedding was sporadic compared to dexamethasone and less efficient in female rabbits. Progesterone significantly increased productive infection in rabbit skin cells, which correlated with stimulating reactivation. These studies suggest progesterone promotes BoHV-1 spread in cattle, in part, by increasing the frequency of reactivation from latency.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Antibodies, Viral
Cattle
Cattle Diseases immunology
Female
Male
Progesterone pharmacology
Rabbits
Sex Factors
Virus Replication drug effects
Virus Replication immunology
Virus Shedding
Cattle Diseases metabolism
Cattle Diseases virology
Herpesviridae Infections veterinary
Herpesvirus 1, Bovine physiology
Progesterone metabolism
Virus Activation drug effects
Virus Activation immunology
Virus Latency drug effects
Virus Latency immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7492
- Volume :
- 276
- Database :
- MEDLINE
- Journal :
- Virus research
- Publication Type :
- Academic Journal
- Accession number :
- 31697987
- Full Text :
- https://doi.org/10.1016/j.virusres.2019.197803