Lanadelumab Injection Treatment For The Prevention Of Hereditary Angioedema (HAE): Design, Development And Place In Therapy.

Despite the efficacy of the on-demand treatment for the control of acute attacks of Hereditary Angioedema due to C1-Inhibitor Deficiency (C1-INH-HAE), the number and severity of attacks and the impairment in the quality of life of the affected patients have led to the development of a new monoclonal antibody, lanadelumab, directly addressed to the blockage of bradykinin, the principal mediator of vasodilation during angioedema attacks. It is indicated for the prophylactic treatment, it is easy to administer, highly effective and with known limited side effects. The current review summarizes the development of the drug, its clinical background and its perspectives.
Competing Interests: Dr Maria Bova reports personal fees and travel grants from Shire - ora Takeda, personal fees and travel grants from CSL behring, outside the submitted work; Dr Anna Valerieva reports grants from Bulgarian Ministry of Science under the National Program for Research, personal fees from Shire/Takeda, personal fees from Pharming Group N.V., personal fees from CSL Behring, outside the submitted work; Dr Riccardo Senter reports travel grants received by Shire-Takeda, CSL Behring, Biocryst and Novartis. The authors report no other conflicts of interests in this work.
(© 2019 Bova et al.)