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Reliable, high-quality suppression of NMR signals arising from water and macromolecules: application to bio-fluid analysis.
- Source :
-
The Analyst [Analyst] 2019 Dec 02; Vol. 144 (24), pp. 7270-7277. - Publication Year :
- 2019
-
Abstract
- Analysis of metabolites in biofluids using nuclear magnetic resonance often requires the suppression of obscuring signals arising from water and macromolecules. This paper analyses the limitations of the pulse sequence most commonly used to achieve such suppression (presat-CPMG) and proposes new pulse sequences that do not share those limitations. The utility of these improved pulse sequences is demonstrated in a metabolomic study of multiple sclerosis (MS) patients.
Details
- Language :
- English
- ISSN :
- 1364-5528
- Volume :
- 144
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- The Analyst
- Publication Type :
- Academic Journal
- Accession number :
- 31693024
- Full Text :
- https://doi.org/10.1039/c9an01005j