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Targeting Immune-Related Biological Processes in Solid Tumors: We do Need Biomarkers.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2019 Nov 01; Vol. 20 (21). Date of Electronic Publication: 2019 Nov 01. - Publication Year :
- 2019
-
Abstract
- Immunotherapy has become the standard-of-care in many solid tumors. Despite the significant recent achievements in the diagnosis and treatment of cancer, several issues related to patients' selection for immunotherapy remain unsolved. Multiple lines of evidence suggest that, in this setting, the vision of a single biomarker is somewhat naïve and imprecise, given that immunotherapy does not follow the rules that we have experienced in the past for targeted therapies. On the other hand, additional immune-related biomarkers that are reliable in real-life clinical practice remain to be identified. Recently, the immune-checkpoint blockade has been approved in the US irrespective of the tumor site of origin. Further histology-agnostic approvals, coupled with with tumor-specific companion diagnostics and guidelines, are expected in this field. In addition, immune-related biomarkers can also have a significant prognostic value. In this review, we provide an overview of the role of these biomarkers and their characterization in the management of lung cancer, melanoma, colorectal cancer, gastric cancer, head and neck cancer, renal cell carcinoma, urothelial cancers, and breast cancer.
- Subjects :
- B7-H1 Antigen metabolism
Breast Neoplasms diagnosis
Breast Neoplasms metabolism
Breast Neoplasms therapy
CTLA-4 Antigen metabolism
Carcinoma, Renal Cell diagnosis
Carcinoma, Renal Cell metabolism
Carcinoma, Renal Cell therapy
Humans
Kidney Neoplasms diagnosis
Kidney Neoplasms metabolism
Kidney Neoplasms therapy
Lung Neoplasms diagnosis
Lung Neoplasms metabolism
Lung Neoplasms therapy
Melanoma diagnosis
Melanoma metabolism
Melanoma therapy
Neoplasms diagnosis
Prognosis
Biomarkers, Tumor metabolism
Immunotherapy methods
Neoplasms metabolism
Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 20
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 31683784
- Full Text :
- https://doi.org/10.3390/ijms20215452