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The hippocampus, prefrontal cortex, and perirhinal cortex are critical to incidental order memory.
- Source :
-
Behavioural brain research [Behav Brain Res] 2020 Feb 03; Vol. 379, pp. 112215. Date of Electronic Publication: 2019 Nov 01. - Publication Year :
- 2020
-
Abstract
- Considerable research in rodents and humans indicates the hippocampus and prefrontal cortex are essential for remembering temporal relationships among stimuli, and accumulating evidence suggests the perirhinal cortex may also be involved. However, experimental parameters differ substantially across studies, which limits our ability to fully understand the fundamental contributions of these structures. In fact, previous studies vary in the type of temporal memory they emphasize (e.g., order, sequence, or separation in time), the stimuli and responses they use (e.g., trial-unique or repeated sequences, and incidental or rewarded behavior), and the degree to which they control for potential confounding factors (e.g., primary and recency effects, or order memory deficits secondary to item memory impairments). To help integrate these findings, we developed a new paradigm testing incidental memory for trial-unique series of events, and concurrently assessed order and item memory in animals with damage to the hippocampus, prefrontal cortex, or perirhinal cortex. We found that this new approach led to robust order and item memory, and that hippocampal, prefrontal and perirhinal damage selectively impaired order memory. These findings suggest the hippocampus, prefrontal cortex and perirhinal cortex are part of a broad network of structures essential for incidentally learning the order of events in episodic memory.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Behavior, Animal physiology
Hippocampus pathology
Hippocampus physiopathology
Male
Memory Disorders pathology
Olfactory Perception physiology
Perirhinal Cortex pathology
Perirhinal Cortex physiopathology
Prefrontal Cortex pathology
Prefrontal Cortex physiopathology
Rats
Rats, Long-Evans
Hippocampus physiology
Memory Disorders physiopathology
Memory, Episodic
Perirhinal Cortex physiology
Prefrontal Cortex physiology
Serial Learning physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7549
- Volume :
- 379
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 31682866
- Full Text :
- https://doi.org/10.1016/j.bbr.2019.112215