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hERG1 and CA IX expression are associated with disease recurrence in surgically resected clear cell renal carcinoma.
- Source :
-
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2020 Jan; Vol. 46 (1), pp. 209-215. Date of Electronic Publication: 2019 Oct 31. - Publication Year :
- 2020
-
Abstract
- Background: In search of novel prognostic biomarkers for clear cell renal carcinoma (ccRCC), we analysed the expression of several proteins related to angiogenesis and hypoxia.<br />Methods: A monocentric study on 30 consecutive surgical samples from surgically-treated ccRCC patients with a 10-year follow up was performed. The following proteins were analysed by immunohistochemistry: Vascular Endothelial Growth Factor- A (VEGF-A), Platelet-Derived Growth Factor β Receptor (PDGFRβ), VEGF-receptor 1 (Flt1), VEGF-receptor 2 (KDR), Glucose Transporter 1 (GLUT1), Carbonic anhydrase IX (CA-IX) and the hERG1 potassium channel. Data were analysed in conjunction with the clinico-pathological characteristics of the patients and follow up.<br />Results: All the proteins were expressed in the samples, with statistically significant associations of VEGF-A with PDGFRβ and Flt1 and hERG1 with CA IX. Notably, hERG1 and CAIX co-immunoprecipitated in primary ccRCC samples and survival analysis showed that the positivity for hERG1 and CA IX had a negative impact on Recurrence Free Survival (RFS) at the univariate analysis. At the multivariate analysis only hERG1 maintained its statistically significant negative impact.<br />Conclusions: hERG1 expression can be exploited to predict recurrence in surgically-treated ccRCC patients. hERG1 channels form a multiprotein complex with the pH regulator CA IX in primary ccRCC samples their potential use as therapeutic target might be suggested.<br /> (Copyright © 2019 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.)
- Subjects :
- Aged
Carcinoma, Renal Cell metabolism
Carcinoma, Renal Cell mortality
Carcinoma, Renal Cell pathology
Female
Humans
Italy
Kidney Neoplasms metabolism
Kidney Neoplasms mortality
Kidney Neoplasms pathology
Male
Middle Aged
Neoplasm Staging
Nephrectomy methods
Prognosis
Survival Rate
Biomarkers, Tumor metabolism
Carbonic Anhydrase IX metabolism
Carcinoma, Renal Cell surgery
Ether-A-Go-Go Potassium Channels metabolism
Kidney Neoplasms surgery
Neoplasm Recurrence, Local metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2157
- Volume :
- 46
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 31679954
- Full Text :
- https://doi.org/10.1016/j.ejso.2019.10.031