Calcium Signaling in Neurons and Glial Cells: Role of Cav1 channels.

Authors :: Alves VS
Alves-Silva HS
Orts DJB
Ribeiro-Silva L
Arcisio-Miranda M
Oliveira FA
Source :: Neuroscience [Neuroscience] 2019 Nov 21; Vol. 421, pp. 95-111. Date of Electronic Publication: 2019 Oct 31.
Publication Year :: 2019
Abstract: Calcium (Ca <superscript>2+</superscript> ) is an essential component in intracellular signaling of brain cells, and its control mechanisms are of great interest in biological systems. Ca <superscript>2+</superscript> can signal differently in neurons and glial cells using the same intracellular pathways or cell membrane structural components. These types of machinery are responsible for entry, permanence, and removal of Ca <superscript>2+</superscript> from the cellular environment and are of vital importance for brain homeostasis. This review highlights the importance of Ca <superscript>2+</superscript> in neuronal and glial cell physiology as well as aspects of learning, memory, and Alzheimer's disease, focusing on the involvement of L-type voltage-gated Ca <superscript>2+</superscript> channels.<br /> (Copyright © 2019 IBRO. Published by Elsevier Ltd. All rights reserved.)