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The Danish model for the quick and safe implementation of infliximab and etanercept biosimilars.
- Source :
-
European journal of clinical pharmacology [Eur J Clin Pharmacol] 2020 Jan; Vol. 76 (1), pp. 35-40. Date of Electronic Publication: 2019 Nov 01. - Publication Year :
- 2020
-
Abstract
- Purpose: A rapidly increasing use of biological drugs has led to substantial costs. Shift to biosimilars enables considerable reduction of these costs without jeopardizing the treatment of patients, but most countries have extensive possibilities of untapped cost-savings. The aim of this study was to describe the Danish quick and near-complete implementation of the two first TNF inhibitor biosimilars (infliximab and etanercept).<br />Methods: We shed light on the considerations and experiences made during the implementation, and present key figures from the implementation.<br />Results: The infliximab biosimilar constituted 90.6% of the total amount of infliximab four months following patent expiration of the biooriginator. Similar results were seen for etanercept biosimilar. Substantial cost reductions were experienced in the way that e.g. the infliximab-shift reduced cost by two thirds.<br />Conclusion: We believe that a thorough preparation and an organizational setting supporting the implementation is crucial for the successful implementation. This same implementation model will be used for future biosimilars.
- Subjects :
- Cost Savings
Denmark
Drug Costs
Etanercept economics
Etanercept therapeutic use
Female
Humans
Infliximab economics
Infliximab therapeutic use
Male
Biosimilar Pharmaceuticals economics
Biosimilar Pharmaceuticals therapeutic use
Tumor Necrosis Factor Inhibitors economics
Tumor Necrosis Factor Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1041
- Volume :
- 76
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 31677117
- Full Text :
- https://doi.org/10.1007/s00228-019-02765-3