Effect of amaranth proteins on the RAS system. In vitro, in vivo and ex vivo assays.

Authors :: Suárez S
Aphalo P
Rinaldi G
Añón MC
Quiroga A
Source :: Food chemistry [Food Chem] 2020 Mar 05; Vol. 308, pp. 125601. Date of Electronic Publication: 2019 Oct 04.
Publication Year :: 2020
Abstract: The aim of this work was to analyse the hypotensive effect of amaranth protein/peptides on spontaneously hypertensive rats (SHR). The mechanism of action of these peptides was studied in vivo and ex vivo. We also tested the effect of protection against gastrointestinal digestion (GID) exerted by an O:W emulsion on the integrity of the antihypertensive peptides. All samples tested produced a decrease in blood pressure (SBP). The animals treated with emulsion (G <subscript>E</subscript> ) and emulsion + peptide (G <subscript>E+VIKP</subscript> ) showed the most significant reduction in the SBP (42 ± 2 mmHg and 35 ± 2 mmHg, respectively). The results presented suggest that after GID, a variety of peptides with biological activities were released or were resistant to this process. These peptides play a role in the regulation of the SBP by acting on plasma ACE, plasma renin and the vascular system. These results support the use of amaranth protein/peptides in the elaboration of functional foods for hypertensive individuals.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Subjects :: Animals
Antihypertensive Agents therapeutic use
Blood Pressure drug effects
Male
Peptides therapeutic use
Plant Proteins pharmacology
Plant Proteins therapeutic use
Rats
Rats, Inbred SHR
Amaranthus chemistry
Antihypertensive Agents pharmacology
Hypertension drug therapy
Peptides pharmacology
Renin-Angiotensin System drug effects

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