Back to Search
Start Over
Paradigms for Precision Medicine in Epichaperome Cancer Therapy.
- Source :
-
Cancer cell [Cancer Cell] 2019 Nov 11; Vol. 36 (5), pp. 559-573.e7. Date of Electronic Publication: 2019 Oct 24. - Publication Year :
- 2019
-
Abstract
- Alterations in protein-protein interaction networks are at the core of malignant transformation but have yet to be translated into appropriate diagnostic tools. We make use of the kinetic selectivity properties of an imaging probe to visualize and measure the epichaperome, a pathologic protein-protein interaction network. We are able to assay and image epichaperome networks in cancer and their engagement by inhibitor in patients' tumors at single-lesion resolution in real time, and demonstrate that quantitative evaluation at the level of individual tumors can be used to optimize dose and schedule selection. We thus provide preclinical and clinical evidence in the use of this theranostic platform for precision medicine targeting of the aberrant properties of protein networks.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Antineoplastic Agents pharmacokinetics
Cell Line, Tumor
Dose-Response Relationship, Drug
Drug Administration Schedule
Epigenesis, Genetic
Female
Gene Expression Regulation, Neoplastic drug effects
Humans
Mice
Molecular Chaperones metabolism
Molecular Imaging
Neoplasms diagnostic imaging
Neoplasms genetics
Neoplasms pathology
Precision Medicine methods
Protein Interaction Mapping methods
Protein Interaction Maps genetics
Theranostic Nanomedicine methods
Xenograft Model Antitumor Assays
Antineoplastic Agents administration & dosage
Molecular Chaperones antagonists & inhibitors
Neoplasms drug therapy
Protein Interaction Maps drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3686
- Volume :
- 36
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Cancer cell
- Publication Type :
- Academic Journal
- Accession number :
- 31668946
- Full Text :
- https://doi.org/10.1016/j.ccell.2019.09.007