Induction of membrane curvature by proteins involved in Golgi trafficking.

Authors :: Makowski SL
Kuna RS
Field SJ
Source :: Advances in biological regulation [Adv Biol Regul] 2020 Jan; Vol. 75, pp. 100661. Date of Electronic Publication: 2019 Oct 16.
Publication Year :: 2020
Abstract: The Golgi apparatus serves a key role in processing and sorting lipids and proteins for delivery to their final cellular destinations. Vesicle exit from the Golgi initiates with directional deformation of the lipid bilayer to produce a bulge. Several mechanisms have been described by which lipids and proteins can induce directional membrane curvature to promote vesicle budding. Here we review some of the mechanisms implicated in inducing membrane curvature at the Golgi to promote vesicular trafficking to various cellular destinations.<br />Competing Interests: Declaration of Competing interest We have no conflicts to report.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)