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Alterations of humoral immunity in patients with gastric cancer.

Authors :
Wu CW
Lui WY
P'eng FK
Wang SR
Source :
Asian Pacific journal of allergy and immunology [Asian Pac J Allergy Immunol] 1988 Jun; Vol. 6 (1), pp. 7-10.
Publication Year :
1988

Abstract

For better understanding of the alterations of humoral immunity in gastric cancer patients, IgG, IgA, IgM, complement C3, C4, CH50, natural antibody (isohemagglutinin-IgM class), ESR, CRP, albumin and globulin were quantitated in sera taken preoperatively from 81 patients with gastric cancer and from 29 control patients with hernia. The results from patients with gastric cancer were grouped according to pTNM staging (including stage I + II, III, and IV). Serum globulin and IgG levels in all stages of cancer patients were significantly lower than that of the controls (p less than 0.05). The CRP and ESR levels in stage III and IV cancer patients were significantly higher (p less than 0.05). There was no difference between cancer and hernia patient groups in IgA, IgM, isohemagglutinin-IgM class, C3, C4, CH50, albumin, WBC and total lymphocyte counts. In conclusion, the significant changes in humoral immunity in patients with gastric cancer include: (1) decrease in serum IgG and globulin levels, and (2) increased levels of acute phase reactants (ESR, CRP). These results imply that patients with gastric cancer have lower acquired humoral immunity and have acute phase reactions.

Details

Language :
English
ISSN :
0125-877X
Volume :
6
Issue :
1
Database :
MEDLINE
Journal :
Asian Pacific journal of allergy and immunology
Publication Type :
Academic Journal
Accession number :
3166645