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Population structure of drug-resistant Mycobacterium tuberculosis in Central Asia.
- Source :
-
BMC infectious diseases [BMC Infect Dis] 2019 Oct 29; Vol. 19 (1), pp. 908. Date of Electronic Publication: 2019 Oct 29. - Publication Year :
- 2019
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Abstract
- Background: Drug-resistant tuberculosis (TB) is a major public health concern threathing the success of TB control efforts, and this is particularily problematic in Central Asia. Here, we present the first analysis of the population structure of Mycobacterium tuberculosis complex isolates in the Central Asian republics Uzbekistan, Tajikistan, and Kyrgyzstan.<br />Methods: The study set consisted of 607 isolates with 235 from Uzbekistan, 206 from Tajikistan, and 166 from Kyrgyzstan. 24-loci MIRU-VNTR (Mycobacterial Interspersed Repetitive Units - Variable Number of Tandem Repeats) typing and spoligotyping were combined for genotyping. In addition, phenotypic drug suceptibility was performed.<br />Results: The population structure mainly comprises strains of the Beijing lineage (411/607). 349 of the 411 Beijing isolates formed clusters, compared to only 33 of the 196 isolates from other clades. Beijing 94-32 (n = 145) and 100-32 (n = 70) formed the largest clusters. Beijing isolates were more frequently multidrug-resistant, pre-extensively resistant (pre-XDR)- or XDR-TB than other genotypes.<br />Conclusions: Beijing clusters 94-32 and 100-32 are the dominant MTB genotypes in Central Asia. The relative size of 100-32 compared to previous studies in Kazakhstan and its unequal geographic distribution support the hypothesis of its more recent emergence in Central Asia. The data also demonstrate that clonal spread of resistant TB strains, particularly of the Beijing lineage, is a root of the so far uncontroled MDR-TB epidemic in Central Asia.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Child
Cross-Sectional Studies
Female
Humans
Kyrgyzstan epidemiology
Male
Middle Aged
Minisatellite Repeats genetics
Molecular Epidemiology
Molecular Typing
Mycobacterium tuberculosis isolation & purification
Phenotype
Tajikistan epidemiology
Tuberculosis, Multidrug-Resistant microbiology
Tuberculosis, Multidrug-Resistant prevention & control
Uzbekistan epidemiology
Young Adult
Epidemics
Genotype
Mycobacterium tuberculosis genetics
Tuberculosis, Multidrug-Resistant epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 31664926
- Full Text :
- https://doi.org/10.1186/s12879-019-4480-7