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Comparison of Chemokine CXCL-1 and Interleukin-6 Concentrations in the Subretinal Fluid and Vitreous in Rhegmatogenous Retinal Detachment.
- Source :
-
Ocular immunology and inflammation [Ocul Immunol Inflamm] 2021 Feb 17; Vol. 29 (2), pp. 355-361. Date of Electronic Publication: 2019 Oct 29. - Publication Year :
- 2021
-
Abstract
- Purpose : Comparison of IL-6 and CXCL-1 concentrations and CXCL-1/IL-6 ratio correlations with clinical parameters (RRD extent, duration, and proliferative vitreoretinopathy - PVR-grade) between subretinal fluid (SRF) and vitreous during rhegmatogenous retinal detachment (RRD) complicated with PVR. Methods : A total of 71 eyes of 71 patients with primary RRD possibly complicated with PVR were included; 36 eyes treated with scleral buckling and 35 eyes with pars-plana vitrectomy. Enzyme-Linked Immuno-sorbent Assay was employed for CXCL-1/IL-6 measurement (ng/ml). Results : Correlation analysis between mean CXCL-1/IL-6 ratio and clinical parameters revealed non-significant results. CXCL-1/IL-6 ratio was significantly elevated in phakic eye vitreous. Optimum circumstances for elevated chemokine levels during RRD were considerable extent (2-3-quadrant) and duration (29-60-day) complicated with PVR C. Conclusions : SRF appears to be characterized by greater chemokine concentrations while vitreous retains several structural characteristics that may assist in investigating inflammation and improving understanding of underlying pathophysiological mechanisms during RRD complicated with PVR.
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers metabolism
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Middle Aged
Retinal Detachment complications
Vitreoretinopathy, Proliferative etiology
Vitreoretinopathy, Proliferative metabolism
Young Adult
Chemokine CXCL1 metabolism
Interleukin-6 metabolism
Retinal Detachment metabolism
Subretinal Fluid metabolism
Vitreous Body metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1744-5078
- Volume :
- 29
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Ocular immunology and inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 31661651
- Full Text :
- https://doi.org/10.1080/09273948.2019.1672197