Vitamin D and the intestine: Review and update.

Authors :: Christakos S
Li S
De La Cruz J
Shroyer NF
Criss ZK
Verzi MP
Fleet JC
Source :: The Journal of steroid biochemistry and molecular biology [J Steroid Biochem Mol Biol] 2020 Feb; Vol. 196, pp. 105501. Date of Electronic Publication: 2019 Oct 23.
Publication Year :: 2020
Abstract: The central role of vitamin D in calcium homeostasis is to increase calcium absorption from the intestine. This article describes the early work that served as the foundation for the initial model of vitamin D mediated calcium absorption. In addition, other research related to the role of vitamin D in the intestine, including those which have challenged the traditional model and the crucial role of specific calcium transport proteins, are reviewed. More recent work identifying novel targets of 1,25(OH) <subscript>2</subscript> D <subscript>3</subscript> action in the intestine and highlighting the importance of 1,25(OH) <subscript>2</subscript> D <subscript>3</subscript> action across the proximal/distal and crypt/villus axes in the intestine is summarized.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)