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Localising movement disorders in childhood.
- Source :
-
The Lancet. Child & adolescent health [Lancet Child Adolesc Health] 2019 Dec; Vol. 3 (12), pp. 917-928. Date of Electronic Publication: 2019 Oct 22. - Publication Year :
- 2019
-
Abstract
- The diagnosis and management of movement disorders in children can be improved by understanding the pathways, neurons, ion channels, and receptors involved in motor learning and control. In this Review, we use a localisation approach to examine the anatomy, physiology, and circuitry of the basal ganglia and highlight the mechanisms that underlie some of the major movement disorders in children. We review the connections between the basal ganglia and the thalamus and cortex, address the basic clinical definitions of movement disorders, and then place diseases within an anatomical or physiological framework that highlights basal ganglia function. We discuss how new pharmacological, behavioural, and electrophysiological approaches might benefit children with movement disorders by modifying synaptic function. A better understanding of the mechanisms underlying movement disorders allows improved diagnostic and treatment decisions.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adolescent
Basal Ganglia anatomy & histology
Cerebral Cortex anatomy & histology
Child
Cognitive Behavioral Therapy methods
Electrophysiological Phenomena physiology
Humans
Motor Neurons physiology
Movement Disorders cerebrospinal fluid
Movement Disorders genetics
Movement Disorders therapy
Synapses physiology
Thalamus anatomy & histology
Young Adult
Basal Ganglia physiology
Cerebral Cortex physiology
Dopamine deficiency
Movement Disorders physiopathology
Thalamus physiology
Subjects
Details
- Language :
- English
- ISSN :
- 2352-4650
- Volume :
- 3
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Lancet. Child & adolescent health
- Publication Type :
- Academic Journal
- Accession number :
- 31653548
- Full Text :
- https://doi.org/10.1016/S2352-4642(19)30330-X