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[Analysis of effects and postoperative clinicopathological prognosis factors of neoadjuvant chemotherapy in patients with stage Ⅰb2 and Ⅱa2 squamous cell carcinoma of the cervix].
- Source :
-
Zhonghua fu chan ke za zhi [Zhonghua Fu Chan Ke Za Zhi] 2019 Oct 25; Vol. 54 (10), pp. 673-679. - Publication Year :
- 2019
-
Abstract
- Objective: To explore the effects and postoperative prognostic factors in cervical cancer patients received neoadjuvant chemotherapy combined with surgery and post-operative adjuvant therapy. Methods: A total of 177 patients with cervical cancer at International Federation of Gynecology and Obstetrics (FIGO) stage Ⅰ b2, Ⅱ a2 who underwent neoadjuvant chemotherapy (NACT) followed by surgery with and without adjuvant therapy in Cancer Hospital, Chinese Academy of Medical Sciences were included. Univariate and multivariate analyses of 5-year overall survival (OS) rate and 5-year disease-free survival (DFS) rate were performed. Results: Of 177 patients, 133 (75.1%) had stage Ⅰb2 and 44 (24.9%) had Ⅱa2 cancers. After NACT, overall response rate was 63.3% (112/177) including 12 cases of complete response (CR), 100 of partial response (PR) and no progressive disease (PD) case. At a median follow-up of 59.2 months, the 5-year DFS rate was 73.6% and the 5-year OS rate was 86.8%. Univariate analysis revealed that lymph node metastasis, deep stromal invasion and tumor size after NACT significantly affected 5-year DFS rate ( P <0.05). Lymph node metastasis, deep stromal invasion and tumor size after NACT significantly affected 5-year OS rate ( P <0.05). The multivariate analysis showed that, stromal invasion (outer 1/3 or outer 1/2) was independent risk factor of 5-year DFS rate ( P <0.05), and 5-year OS rate was significantly affected by tumor size >3 cm after NACT ( P <0.05). Conclusions: The effect of NACT in Ⅰ b2, Ⅱ a2 squamous carcinoma of the uterined cervix is confirmed. The independent risk factor for 5-year DFS rate in patients received NACT and hysterectomy is deep stromal invasion of the cervix. The presence of tumor size >3 cm after NACT adversely affect 5-year OS rate.
- Subjects :
- Combined Modality Therapy
Female
Humans
Neoplasm Staging
Postoperative Period
Prognosis
Retrospective Studies
Treatment Outcome
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell therapy
Chemotherapy, Adjuvant methods
Hysterectomy
Neoadjuvant Therapy
Uterine Cervical Neoplasms pathology
Uterine Cervical Neoplasms therapy
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0529-567X
- Volume :
- 54
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Zhonghua fu chan ke za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 31648443
- Full Text :
- https://doi.org/10.3760/cma.j.issn.0529-567x.2019.10.005