Obesity Paradox in Caucasian Seniors: Results of the PolSenior Study.

Objectives: To investigate the influence of overweight and obesity on general performance and mortality in seniors.
Design: Cross-sectional multidisciplinary study on ageing of the Polish population.
Setting: Community-dwelling individuals aged 65 years or older, selected using three-stage stratified, proportional draw.
Participants: 4944 Polish Caucasian seniors, aged 65 years or older recruited between October 2007 and October 2010.
Measurements: All study subjects underwent measurement of body mass index (BMI), waist circumference (WC), and arm circumference (AC). The physical and cognitive performance was evaluated using the Katz Activities of Daily Living (ADL) score and Mini-Mental State Examination (MMSE), respectively. Morbidity data were obtained from a medical questionnaire. Mortality data were obtained from the Population Register of Poland between October 2015 and October 2018.
Results: Increasing age was associated with a decreased prevalence of obesity (all p<0.001). Higher BMI, WC and AC values were associated with higher ADL and MMSE scores (all p<0.001). On multivariate analysis, all three body measurements in women remained independent predictors of the ADL score (BMI p=0.002, WC p=0.005, AC p<0.001) and MMSE score (p<0.001, p=0.003, p<0.001). In men, physical functioning was associated with AC (p=0.003), and cognitive status was associated with AC (p<0.001) and BMI (p=0.013). There was no association between general obesity, abdominal obesity, or AC with several aging-related adverse conditions. Kaplan-Meier survival curves showed that overweight and obesity were associated with the lowest mortality. On multivariate analysis, BMI and AC values remained independent predictors of mortality. In successfully aging individuals, neither BMI, WC, nor AC remained such predictors.
Conclusions: Overweight and obesity in Caucasian seniors are not associated with deterioration of physical and cognitive function or with increased mortality.
Competing Interests: The authors have no conflicts of interest to declare