Back to Search
Start Over
Cerebral gliosarcoma with perivascular involvement in a cat.
- Source :
-
JFMS open reports [JFMS Open Rep] 2019 Oct 10; Vol. 5 (2), pp. 2055116919879783. Date of Electronic Publication: 2019 Oct 10 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Case Summary: A 5-year-old neutered male domestic shorthair cat presented with an 18-month history of facial tics, and progressive general ataxia, weakness, lethargy and anorexia of 2 weeks' duration. MRI of the brain showed a well-defined heterogeneous hyperintense mass on T1-weighted and T2-weighted images, with central hypointensity in the rostral commissure and septum pellucidum, and perilesional hyperintensity in fluid-attenuated inversion recovery, suggestive of perilesional oedema. Gross examination in a transverse section of the brain at the level of the septum pellucidum revealed a 0.2 cm brown soft mass. Histopathological examination identified a biphasic neoplastic proliferation of mesenchymal and neuroepithelial cell populations. Fusiform cells were predominately distributed in bundles showing a high degree of anisocytosis and marked immune-positive reaction to vimentin immunochemistry, confirming a sarcomatous origin. Additionally, high numbers of astrocytic cells were identified by an intense immunopositive reaction to glial fibrillary acidic protein and negative reaction to oligodendrocyte transcription factor 2 immunochemistry. Vascular invasion of the neoplasia into the wall of a medium branch of the rostral cerebral artery was present (secondary Scherer structures). Based on these characteristics, the tumour was defined as a gliosarcoma. Gliosarcoma is a recognised astrocytoma grade IV anaplastic glial cell tumour with sarcomatous differentiation.<br />Relevance and Novel Information: To our knowledge, this is the first report describing a cerebral gliosarcoma in a cat including clinical, MRI, macroscopic and histopathological features and immunolabelling characteristics.<br />Competing Interests: Conflict of interest: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.<br /> (© The Author(s) 2019.)
Details
- Language :
- English
- ISSN :
- 2055-1169
- Volume :
- 5
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- JFMS open reports
- Publication Type :
- Report
- Accession number :
- 31636916
- Full Text :
- https://doi.org/10.1177/2055116919879783