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HIV Prevalence and Morbidity in Older Inpatients in a High HIV Prevalence Setting.
- Source :
-
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2020 Mar; Vol. 36 (3), pp. 186-192. Date of Electronic Publication: 2019 Dec 10. - Publication Year :
- 2020
-
Abstract
- Understanding of the burden of HIV infection and comorbid conditions in older adults is limited, especially in low- and middle-income countries. Antiretroviral therapy (ART) has increased longevity of HIV-positive individuals, making age-related comorbidities more likely. This study aimed to compare the demographic and disease profiles, including chronic comorbid conditions of inpatients, at least 50 years of age, by HIV status, admitted to a regional hospital in South Africa. Adults, 50 years of age and older, admitted to internal medicine wards from November 2015 to February 2016 were approached to participate. Sociodemographic data, laboratory results, anthropometric data, discharge diagnoses, and HIV status were collected and compared by HIV serostatus. Overall, 151 participants were enrolled. Their median age was 61 years (IQR: 56-68 years); 89 (58.9%) were women. Overall, 47 (31.1%) were HIV positive, of whom 10 (6.6%) were first diagnosed during the admission. HIV-positive inpatients were younger than HIV-negative patients. The leading discharge diagnoses of all participants were acute gastroenteritis (11.5%) and community-acquired pneumonia (11.5%). Hypertension and type 2 diabetes mellitus (T2DM) were the leading comorbidities in both HIV-negative and HIV-positive participants. Prevalence of hypertension was 75.0% in seronegative, 59.5% in those with a prior diagnosis of HIV, and 40.0% in newly diagnosed; similarly, prevalence of T2DM was 22.1% in HIV-negative and 24.3% in known HIV-positive participants. Similar proportions died during admission; 11.3% of HIV-negative and 12.7% of HIV-positive admitted inpatients died. Almost one third of patients admitted were HIV positive. In HIV-positive older admitted to hospital, the leading cause for hospitalization was coinfections. In the ART era, irrespective of HIV status, older patients have similar age-related chronic illnesses and similar mortality rates, despite younger age at admission.
- Subjects :
- Age Factors
Aged
Cross-Sectional Studies
Diabetes Mellitus, Type 2 epidemiology
Female
HIV Infections mortality
Hospitalization statistics & numerical data
Humans
Hypertension epidemiology
Inpatients statistics & numerical data
Male
Middle Aged
Prevalence
Prospective Studies
South Africa epidemiology
HIV Infections epidemiology
Morbidity
Subjects
Details
- Language :
- English
- ISSN :
- 1931-8405
- Volume :
- 36
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- AIDS research and human retroviruses
- Publication Type :
- Academic Journal
- Accession number :
- 31631667
- Full Text :
- https://doi.org/10.1089/AID.2019.0137