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Complement inhibition in ANCA vasculitis.
- Source :
-
Nephrologie & therapeutique [Nephrol Ther] 2019 Nov; Vol. 15 (6), pp. 409-412. Date of Electronic Publication: 2019 Oct 17. - Publication Year :
- 2019
-
Abstract
- A role for the alternative complement pathway has emerged in the understanding of ANCA vasculitis pathogenesis. Current therapies of ANCA vasculitis are limited by partial efficacy and toxicity and many patients pursue a relapsing course. Improved therapies are needed. Inhibition of the alternative complement pathway component C5a is attractive due to its role in neutrophil activation and migration, and engagement of other inflammatory and thrombotic mechanisms. Two inhibitors of C5a are in clinical development for ANCA vasculitis: avacopan, an oral C5a receptor inhibitor has demonstrated efficacy, safety and steroid sparing in two Phase II trials; and IFX-1, a monoclonal antibody to C5a which is entering Phase II development. Complement inhibition has the potential to contribute to remission induction protocols achieving a higher quality of remission as well as replacing steroids. Confirmation of safety, especially infective risk, and the potential to replace steroids depends on further studies and a role in relapse prevention needs to be explored.<br /> (Copyright © 2019 Société francophone de néphrologie, dialyse et transplantation. Published by Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Aniline Compounds pharmacology
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis drug therapy
Antibodies, Monoclonal pharmacology
Clinical Trials, Phase II as Topic
Complement C5a immunology
Complement Inactivating Agents pharmacology
Humans
Neutrophil Activation drug effects
Nipecotic Acids pharmacology
Aniline Compounds therapeutic use
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis immunology
Antibodies, Monoclonal therapeutic use
Complement C5a antagonists & inhibitors
Complement Inactivating Agents therapeutic use
Complement Pathway, Alternative drug effects
Nipecotic Acids therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9177
- Volume :
- 15
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nephrologie & therapeutique
- Publication Type :
- Academic Journal
- Accession number :
- 31631015
- Full Text :
- https://doi.org/10.1016/j.nephro.2019.04.001