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A Translational Model of Chronic Heart Failure.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2019 Sep; Vol. 167 (5), pp. 706-710. Date of Electronic Publication: 2019 Oct 19. - Publication Year :
- 2019
-
Abstract
- We created a translational model of chronic heart failure in rats that developed in 3 months after reproducing experimental anterior transmural myocardial infarction. The model simulated the basic clinicodiagnostic criteria of this disease: impaired contractility and dilatation of heart ventricles, signs of venous congestion, elevated plasma content of biochemical markers, and abnormal overexpression of AT1aR and β-adrenoceptors.
- Subjects :
- Animals
Animals, Outbred Strains
Biomarkers metabolism
Echocardiography
Gene Expression
Heart Failure diagnostic imaging
Heart Failure genetics
Heart Failure metabolism
Heart Ventricles diagnostic imaging
Heart Ventricles metabolism
Hemodynamics physiology
Humans
Male
Myocardial Contraction physiology
Myocardial Infarction diagnostic imaging
Myocardial Infarction genetics
Myocardial Infarction metabolism
Myocardium metabolism
RNA, Messenger genetics
RNA, Messenger metabolism
Rats
Receptor, Angiotensin, Type 1 genetics
Receptor, Angiotensin, Type 1 metabolism
Receptors, Adrenergic, beta-1 genetics
Receptors, Adrenergic, beta-1 metabolism
Receptors, Adrenergic, beta-2 genetics
Receptors, Adrenergic, beta-2 metabolism
Translational Research, Biomedical methods
Disease Models, Animal
Heart Failure physiopathology
Heart Ventricles physiopathology
Myocardial Infarction physiopathology
Myocardium pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-8221
- Volume :
- 167
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 31630305
- Full Text :
- https://doi.org/10.1007/s10517-019-04604-y