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Early hypoalbuminemia is associated with 28-day mortality in severely burned patients: A retrospective cohort study.
- Source :
-
Burns : journal of the International Society for Burn Injuries [Burns] 2020 May; Vol. 46 (3), pp. 630-638. Date of Electronic Publication: 2019 Oct 16. - Publication Year :
- 2020
-
Abstract
- Background: Hypoalbuminemia is a frequent condition in the first 24 h after a severe burn injury and is associated with worse outcomes.<br />Methodology: We investigated the relation between very early hypoalbuminemia (<6 h after admission) and clinical outcome in a retrospective cohort admitted to our unit for severe burn injuries between 2012 and 2017.<br />Results: 73 severely burned patients were included, with a delay of admission of 3 (2-4) h. In a context of early exogenous supply of albumin, admission and 4H Albuminemia (Alb4 h) were significantly lower in deceased patients (respectively, 34 (29-37) vs 27 (23-30) g/l; p = 0.009 and 27 (24-32) vs 21 (17-27) g/l; p = 0.022) whereas albuminemia ≥6 h were not. The best threshold value of Alb4 h to discriminate 28-day mortality was 23 g/l. Patients with an Alb4 h < 23 g/l had a higher 28-day mortality than patients with an Alb4 h ≥ 23 g/l (42% vs 11%; p = 0.003); adjusted OR = 4.47 (95% CI 1.15-17.36); p = 0.03.<br />Conclusion: In severely burned patients receiving early albumin supply, early hypoalbuminemia is associated with higher mortality whereas later albuminemia (≥6 h) is not. Exploration of whether early albumin infusion (8-12 h post injury) may alter clinical outcome is warranted.<br /> (Copyright © 2019 Elsevier Ltd and ISBI. All rights reserved.)
- Subjects :
- Acute Kidney Injury epidemiology
Adult
Aged
Albumins therapeutic use
Burn Units
Burns therapy
Cohort Studies
Crystalloid Solutions therapeutic use
Female
Fluid Therapy methods
Humans
Length of Stay
Male
Middle Aged
Prognosis
Renal Replacement Therapy statistics & numerical data
Respiration, Artificial
Respiratory Distress Syndrome epidemiology
Retrospective Studies
Sepsis epidemiology
Time Factors
Trauma Severity Indices
Burns metabolism
Capillary Permeability
Hypoalbuminemia epidemiology
Mortality
Serum Albumin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1409
- Volume :
- 46
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Burns : journal of the International Society for Burn Injuries
- Publication Type :
- Academic Journal
- Accession number :
- 31629616
- Full Text :
- https://doi.org/10.1016/j.burns.2019.09.013