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Clinicopathologic Characterization of Post-Renal Transplantation BK Polyomavirus-Associated Urothelial CarcinomaSingle Institutional Experience.
- Source :
-
American journal of clinical pathology [Am J Clin Pathol] 2020 Feb 08; Vol. 153 (3), pp. 303-314. - Publication Year :
- 2020
-
Abstract
- Objectives: To review rare cases of BK polyomavirus (BKPyV) associated urologic carcinomas in kidney transplant recipients at one institution and in the literature.<br />Methods: We describe the clinicopathologic features of BKPyV-associated urologic carcinomas in a single-institution cohort.<br />Results: Among 4,772 kidney recipients during 1994 to 2014, 26 (0.5%) and 26 (0.5%) developed posttransplantation urothelial carcinomas (UCs) and renal cell carcinomas (RCCs), respectively, as of 2017. Six (27%) UCs but none of the RCCs expressed large T antigen (TAg). TAg-expressing UCs were high grade with p16 and p53 overexpression (P < .05 compared to TAg-negative UCs). Tumor genome sequencing revealed BKPyV integration and a lack of pathogenic mutations in 50 cancer-relevant genes. Compared to TAg-negative UCs, TAg-expressing UCs more frequently presented at advanced stages (50% T3-T4) with lymph node involvement (50%) and higher UC-specific mortality (50%).<br />Conclusions: Post-renal transplantation BKPyV-associated UCs are aggressive and genetically distinct from most non-BKPyV-related UCs.<br /> (© American Society for Clinical Pathology, 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Adult
Aged
BK Virus
Carcinoma, Renal Cell etiology
Carcinoma, Transitional Cell etiology
Female
Humans
Kidney pathology
Kidney Neoplasms etiology
Male
Middle Aged
Polyomavirus Infections etiology
Postoperative Complications etiology
Postoperative Complications pathology
Retrospective Studies
Tumor Virus Infections etiology
Carcinoma, Renal Cell pathology
Carcinoma, Transitional Cell pathology
Kidney Neoplasms pathology
Kidney Transplantation adverse effects
Polyomavirus Infections pathology
Tumor Virus Infections pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1943-7722
- Volume :
- 153
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- American journal of clinical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 31628837
- Full Text :
- https://doi.org/10.1093/ajcp/aqz167