Back to Search
Start Over
Identification of pigments related to allergic tattoo reactions in 104 human skin biopsies.
- Source :
-
Contact dermatitis [Contact Dermatitis] 2020 Feb; Vol. 82 (2), pp. 73-82. Date of Electronic Publication: 2019 Nov 18. - Publication Year :
- 2020
-
Abstract
- Background: Red tattoos are prone to allergic reactions. The identity of the allergen(s) is mostly unknown.<br />Objectives: Chemical analysis of human skin biopsies from chronic allergic reactions in red tattoos to identify culprit pigment(s) and metals.<br />Material and Methods: One hundred four dermatome biopsies were analyzed by matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-MS/MS) for identification of commonly used organic pigments. Metal concentrations were assessed by inductively coupled plasma (ICP)-MS and x-ray fluorescence (XRF). Fourteen patients had cross-reactions in other red tattoos.<br />Results: In total, the identified pigments were mainly azo Pigment Red (P.R.) 22 (35%), P.R. 210 (24%), P.R. 170 (12%), P.R. 5 (0.9%), P.R. 112 (0.9%), and Pigment Orange (P.O.) 13 (11%). P.R. 122 (0.9%) and Pigment Violet (P.V.) 23 (8%) were also common. P.R. 22, P.R. 170, and P.R. 210 also dominated in patients with cross-reactions. In 22% of the biopsies, no red pigment was detected. Element analysis indicated the presence of the sensitizers nickel and chromium.<br />Conclusions: P.R. 22, P.R. 170, and P.R. 210 were identified as the prevailing pigments behind chronic allergic reactions in red tattoos. The epitope causing the reaction might be a pigment-degradation product. Metal contamination may derive from different sources, and its role in red tattoo allergy cannot be ascertained.<br /> (© 2019 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1600-0536
- Volume :
- 82
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Contact dermatitis
- Publication Type :
- Academic Journal
- Accession number :
- 31626330
- Full Text :
- https://doi.org/10.1111/cod.13423