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Prospective evaluation of oral premalignant lesions using a multimodal imaging system: a pilot study.
- Source :
-
Head & neck [Head Neck] 2020 Feb; Vol. 42 (2), pp. 171-179. Date of Electronic Publication: 2019 Oct 17. - Publication Year :
- 2020
-
Abstract
- Background: Multimodal optical imaging, incorporating reflectance and fluorescence modalities, is a promising tool to detect oral premalignant lesions in real-time.<br />Methods: Images were acquired from 171 sites in 66 patient visits for clinical evaluation of oral lesions. An automated algorithm was used to classify lesions as high- or low-risk for neoplasia. Biopsies were acquired at clinically indicated sites and those classified as high-risk by imaging, at the surgeon's discretion.<br />Results: Twenty sites were biopsied based on clinical examination or imaging. Of these, 12 were indicated clinically and by imaging; 58% were moderate dysplasia or worse. Four biopsies were indicated by imaging evaluation only; 75% were moderate dysplasia or worse. Finally, four biopsies were indicated by clinical evaluation only; 75% were moderate dysplasia or worse.<br />Conclusion: Multimodal imaging identified more cases of high-grade dysplasia than clinical evaluation, and can improve detection of high grade precancer in patients with oral lesions.<br /> (© 2019 The Authors. Head & Neck published by Wiley Periodicals, Inc.)
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 42
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 31621979
- Full Text :
- https://doi.org/10.1002/hed.25978