Light-activated drug release from prodrug nanoassemblies by structure destruction.

Authors :: Li Y
Wang S
Huang Y
Chen Y
Wu W
Liu Y
Zhang J
Feng Y
Jiang X
Gou M
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Oct 29; Vol. 55 (87), pp. 13128-13131.
Publication Year :: 2019
Abstract: We report here a novel light-triggered nanosystem based on co-assembling nanoaggregates (NAs) of lipophilic photosensitizers and lipophilic prodrugs containing multiple thioethers. Upon laser irradiation, the oxidization of the multiple thioethers by photosensitizer-generated singlet oxygen could rapidly destroy the NA structure, resulting in faster drug release than those containing a single thioether.

Subjects :: Cell Line, Tumor
Cell Survival drug effects
Drug Liberation
Humans
Molecular Structure
Particle Size
Photosensitizing Agents pharmacology
Prodrugs pharmacology
Singlet Oxygen chemistry
Sulfides pharmacology
Surface Properties
Light
Nanoparticles chemistry
Photosensitizing Agents chemistry
Prodrugs chemistry
Sulfides chemistry

Full Text Access

Tools