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Molecular Tweezers-like Calix[4]arene Based Alkaline Earth Metal Cation (Ca 2+ , Sr 2+ , and Ba 2+ ) Chemosensor and Its Imaging in Living Cells and Zebrafish.
- Source :
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Inorganic chemistry [Inorg Chem] 2019 Nov 04; Vol. 58 (21), pp. 14720-14727. Date of Electronic Publication: 2019 Oct 15. - Publication Year :
- 2019
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Abstract
- Although alkaline earth metal cations play an important role in our daily life, little attention has been paid to the field of fast quantitative analysis of their content due to a lack of satisfactory precision and a fast and convenient means of detection. In this study, we have designed a set of molecular tweezers based on the calix[4]arene chemosensor L , which was found to exhibit high selectivity and sensitivity toward Ca <superscript>2+</superscript> , Sr <superscript>2+</superscript> , and Ba <superscript>2+</superscript> (by UV-vis and fluorescence methods) with low detection limits of the order of 10 <superscript>-7</superscript> to 10 <superscript>-8</superscript> M and high association constants (of the order of 10 <superscript>6</superscript> ). More significantly, sensor L not only can recognize Ca <superscript>2+</superscript> , Sr <superscript>2+</superscript> , and Ba <superscript>2+</superscript> but also can further discriminate between these three cations via the differing red shifts in their UV-vis spectra (560 nm for L ·Ca <superscript>2+</superscript> , 570 nm for L ·Sr <superscript>2+</superscript> , and 580 nm for L ·Ba <superscript>2+</superscript> complex) which is attributed to their different atomic radii. A rare synergistic effect for the recognition mechanism has been demonstrated by <superscript>1</superscript> H NMR spectroscopic titration. Sensor L constructed a high shielding field by the cooperation of Tris with alkaline earth metal ion after complex. Additionally, the presence of acetoxymethyl group in sensor L results in enhancement of cell permeability, and as a consequence, sensor L exhibited excellent sensing and imaging ( in vivo ) in living cells and in zebrafish.
Details
- Language :
- English
- ISSN :
- 1520-510X
- Volume :
- 58
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Inorganic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 31613605
- Full Text :
- https://doi.org/10.1021/acs.inorgchem.9b02364