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Antiretroviral Penetration across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 Dec 20; Vol. 64 (1). Date of Electronic Publication: 2019 Dec 20 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- For HIV cure strategies like "kick and kill" to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We characterize penetration of six ARVs in three preclinical animal models and humans. We found that standard dosing strategies in preclinical species closely mimicked tissue concentrations in humans for some, but not all, ARVs. These results have implications for interpreting HIV treatment, prevention, or cure interventions between preclinical and clinical models.<br /> (Copyright © 2019 American Society for Microbiology.)
- Subjects :
- Animals
Anti-HIV Agents therapeutic use
Atazanavir Sulfate therapeutic use
Emtricitabine therapeutic use
Female
Humans
In Vitro Techniques
Maraviroc therapeutic use
Mice
Raltegravir Potassium therapeutic use
Tenofovir therapeutic use
Anti-Retroviral Agents therapeutic use
HIV Infections drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 64
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 31611355
- Full Text :
- https://doi.org/10.1128/AAC.01639-19